Principles and advantages of non-invasive fetal paternity testing

Non-invasive paternity testing of the fetus in the womb is also called prenatal paternity testing, pregnancy paternity testing, and maternal paternity testing. It refers to the extraction of venous blood from pregnant women after pregnancy, and the independent DNA of the fetus is extracted through a new generation of DNA sequencing technology. It is then compared with the DNA of the suspected father to find out who the biological father of the fetus is.

In 1997, Lo et al. (Lo Y.M.et al.1997.lancet) confirmed that the plasma of pregnant women contains cell-free fetal DNA (cffDNA), which provides a basis for non-invasive fetal paternity testing.

The non-invasive fetal paternity testing technology selects SNP loci for detection, enriches SNP loci by liquid intersection capture method, genotypes through high-throughput sequencing, and finally determines whether there is a parent-child relationship between parents and children according to Mendelian inheritance rules.

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